Angioedema -Quick revision card

First described by Quincke in 1882 , AKA angioneurotic edema , Quincke's edema transient , typically non-pruritic , non-pitting swelling just below the skin ( subcutanous and/ or submucosal ) mostly affects the face , lips , neck , extremities , oral cavity ( serious -life threatening if it affects larynx ) ie affects areas with loose connective tissue distinct to oedema ( fluid accumulates in the interstitium -persistent pitting with pressure ) angiodema is due to ↑↑ ed vascular permeability can occur in isolation or or accompanied by urticaria ( 50 % cases ) or as a feature of anaphylaxis mediated by histamine , bradykinin or other mechanisms.

Axquired allergic ( associated with anaphylaxis ) non-allergic drug induced complement mediated idiopathic ( further divided into histaminergic & non histaminergic )

Hereditary Autosomal dominant condition due to mutation in the gene encoding for C1-esterase inhibitor HAE type 1 ( low plasma conc of C1 ) HAE type 2 ( normal conc of functionally impaired C1 )

Histamine mediated -responds to antihistamines○ similar to anaphylaxis○ 50 % with urticaria○ occurs quickly○ typically self limiting over 24 hrs○ h/o atopy ?○ foods , medications , stinging insect venoma , radio contrast ,NSAID...