Antiphospholipid syndrome

Antiphospholipid syndrome ( APS ) is a systemic autoimmune disorder with a wide range of vascular and obstetric manifestations associated with thrombotic and inflammatory mechanisms orchestrated by antiphospholipid ( aPL ) antibodies ( Tektonidou MG et al EULAR recommendations for the management of antiphospholipid syndrome in adults 2019 )

a rare disease ( estimated prevalence 5 cases per 1000,000 people / year ) most common cause of acquired thrombophilia , in people < 50 can be responsible for ○ 15 % to 20 % of all DVT episodes○ 1/3rd of new CVA cases○ recurrent fetal loss ( e,g 3 or + losses < 10 wks gestation , 1 or + losses ≥ 10 wks gestation , pre-term birth < 34 wks due to eclampsia , pre-eclampsia or placental insufficiency ) vascular thrombosis can be arterial , venous or small vessel , can affect any organ or tissue but the most common sitesare of venous & arterial thrombosis are the lower limbs and the cerebral arterial circulation Various diagnostic criteria exist as The International consensus ( revised Sapporo ) criteria for diagnosis for diagnosis pf obstetric antiphospholipid syndrome patients may also develop less frequent other organ involvement related to APS ,...