Carbimazole

Carbimazole is a thionamide class antithyroid drug commonly used to manage hyperthyroidism. It acts as a prodrug, rapidly and completely converting to its active metabolite, methimazole (also known as thiamazole), once administered. The primary mechanism by which carbimazole functions involves inhibiting the organification of iodide and the coupling of iodothyronine residues, processes crucial for the synthesis of thyroid hormones. This reduction in hormone production helps control the excessive hormonal activity seen in hyperthyroid conditions.

The clinical effects of carbimazole can take between four to eight weeks to fully manifest, with typical maintenance dosages ranging from 5 to 30 mg per day. This medication is pivotal in the management of hyperthyroid symptoms and in achieving and maintaining a euthyroid state in affected patients.