Chronic Fatigue Syndrome ( CFS_ ME )-Diagnosis

Chronic Fatigue Syndrome ( CFS ) is a complex chronic disorder of unknown etiology characterized by the presence of intense and disabling fatigue ( physical and mental ) , with a clinical course and without any apparent cause which interferes with daily activities , does not decrease with rest , worsens with exercise and is usually associated to systemic , physical and neurophysiological manifestations ( Ballester M et al 2002 , Strauss S Harrison's Principles of Internal Medicine 2006 )

Background -Described in 18th century by Hammurabi ( Babylonian philosopher ) Systemic Exertion Intolerance Disease ( SIED ) proposed by US Institute of Medicine Myalegic encephalopathy/ encephalomyelitis - the terms ME and CFS have been conflated and as of 2016 US Federal health agencies use the combined term ME/ CFS to refer to the disease Immune dysfunction syndrome , Neuroendocrine immune dysfunction syndrome Post-viral syndrome Royal Free Disease ( outbreak in 1955 at Royal Free Hospital in London ) Neurasthenia

Epedmiology -Prevalence is difficult to predict due to- diagnostic criteria used may vary fundamentally- depends on the study population / design- data has started to be available from 1990 only and studies have been carried out mostly in Europe and...