Crohn’s disease

Crohn's disease is a chronic inflammatory disease that mainly affects the gastrointestinal tract. It is characterized by transmural inflammation ( extending through all layers ) , deep ulceration and fissuring of the mucosa and the presence of granulomas .It may involve any or all parts of the entire GI tract from mouth to peri-anal area ( although seen usually in terminal ileum and perianal locations ) interspersed with areas of relatively normal tissue

Rising incidence and prevalence globally Currently no cure for IBD Affects about 1 in 300 people in the Western World At-least 115,000 people in UK with Crohn's disease ( NICE 2012 ) Can occur at any age but most commonly presents in adolescence and early adulthood 20-30 % cases present in people < 20 yrs Median age of diagnosis is 30 yrs Occurs with equal rate in men and women Rising incidence and prevalence globally A Lancet report mentions that the prevalence of IBD has increased substantially in many regions from 1990-2017 ( Jairath et al 2017 ) CD is more common in the industrialized world ( N America and Western Europe ) At-least 115,000 people in UK with Crohn's disease ( NICE 2012 ) About 70,000...