Dementia with Lewy Bodies ( DLB )

This table provides an organized guide and quick overview for primary care practitioners on DLB, covering its definition, prevalence, diagnostic criteria, the necessary workup for its diagnosis, and its differentiation from similar conditions.

Central to the pathology of LBD is the accumulation of Lewy bodies within the brain's neuronal cells. These are intraneuronal cytoplasmic inclusion bodies primarily composed of aggregates of alpha-synuclein and ubiquitin. The widespread distribution of Lewy bodies across various brain regions correlates with the diverse clinical manifestations observed in LBD.

Column	Description
Definition	•DLB is an age-related neurodegenerative disorder leading to progressive cognitive decline disrupting everyday life. The condition is characterized by the accumulation of α-synuclein protein in Lewy bodies, similar to Parkinson’s disease (PD). • Motor features of PD are common but aren't essential for a DLB diagnosis.
Epidemiology	• Dementia is marked by symptoms like memory loss, mood shifts, and altered communication. • Of every 100 dementia cases, 10-15 are DLB, equating to approximately 100,000 affected individuals in the UK. DLB originates from the build-up of the alpha-synuclein protein in nerve cells, leading to the formation of Lewy bodies that damage these cells. This impacts brain functions related to thinking, memory, and movement. • DLB...

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Description

Definition

•DLB is an age-related neurodegenerative disorder leading to progressive cognitive decline disrupting everyday life. The condition is characterized by the accumulation of α-synuclein protein in Lewy bodies, similar to Parkinson’s disease (PD).
• Motor features of PD are common but aren't essential for a DLB diagnosis.

Epidemiology

• Dementia is marked by symptoms like memory loss, mood shifts, and altered communication.
• Of every 100 dementia cases, 10-15 are DLB, equating to approximately 100,000 affected individuals in the UK. DLB originates from the build-up of the alpha-synuclein protein in nerve cells, leading to the formation of Lewy bodies that damage these cells. This impacts brain functions related to thinking, memory, and movement.
• DLB...

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