Dupuytren’s disease -Quick revision card

progressive , irreversible and often bilateral ,affects the palmar fascia benign nodular proliferative process of palmar aponeurosis connective tissue under the skin of the palm contracts and becomes tough over time type III collagen which is thicker than type I is laid gradually collagen knots and fibres in the palmar fascia are formed 3 recognised stages ( 1 ) proliferative (2 ) involution (3 ) residual fascial bands change into pathological cords -causing deformity eventually thick collagen cords cause flexion deformity of the affected metacarpophalangeal joint ( MPJ ) or proximal interphalangeal joint

Risk factors - family history ancestry ( Northern Europeandescent ) male sex age ( increases with age ) more common in heavy smokers low body weight elevated fasting blood glucose , diabetes epilepsy carpal tunnel syndrome h/o or current manual labor hypercholesterolaemia hand injury

What happens also known by other names as Dupuytren’s disease , palmar fibromatosis common fibroproliferative disabling disorder affecting the palmar surface of hands , mostly seen in Caucasians of Northwestern European origin inherited connective tissue disorder ( inheritance may be autosomal dominant but often the aetiology is multifactorial ) prevalence increases with age & men suffer more than women affects typically white middle...