Head and neck cancers

Head and neck cancers ( HNC ) ) represent 3rd most common cause of cancer death worldwide HNC is the 5th most frequent cancer worldwide (or 6th as per Over 30 specific sites in the head & neck region can be involved and the vast majority ( > 90 % ) are squamous cell carcinomas ( HNSCCs ) and the disease typically appears in the oropharynx , oral cavity , hypopharynx or larynx HNSCC originate from the mucosal epithelial cells that line the oral cavity , pharynx , larynx and the sinonasal tract The tumour can vary in location , pathophysiology , biological behavior and sensitivity to treatment Global burden of HNC ( in 2018 ) -650,000 new cases and 350,000 deaths worldwide / year and major proportion of regional malignancies in India In the UK in 2014 there were 11,400 new cases Men suffer more with male : female ration of 7 : 1 Median age of non-virally associated HNSCC is 66 yrs whereas for HPV associated oropharyngeal cancers and EBV associated nasopharyngeal cancer is 53 yrs & 50 yrs respectively The incidence of HNC has increased over the last few decades with an increase in use and exposure...