Hormone replacement therapy ( HRT) : Progestogens

Progestogens play a critical role in hormone replacement therapy (HRT), especially for women with an intact uterus. They are used alongside estrogen to prevent endometrial hyperplasia, which can lead to cancer due to the unopposed action of estrogen. Progestogens help balance estrogen's effects by providing a protective action on the uterine lining, ensuring it remains healthy.

The various types of progestogens used in HRT include both natural and synthetic forms, each with different properties, efficacy profiles, and side effect potentials. These differences are important to consider when tailoring HRT to meet individual therapeutic needs and manage the risks associated with menopause and perimenopause effectively. Understanding the types and characteristics of progestogens helps in selecting the most suitable regimen, enhancing both the safety and effectiveness of hormone therapy.

Women’s tolerance to different progestogens can vary significantly. It may be necessary to switch the progestogen component in HRT if adverse effects, such as mood changes or fluid retention, occur.