Hypoalbuminemia- Low albumin

Hypoalbuminaemia is low serum albumin level.Most abundant plasma protein Accounts for 75-80 % of normal plasma colloid oncotic pressure and 40-60 % of total protein content Half life 15-19 days.

Functions -Maintains colloid oncotic pressure- prevents leaking of fluid into the extravascular space Transports various agents Low-affinity , high capacity carrier of several different endogenous and exogenous compounds acting as a depot and a carrier of these compounds Binds atleast 40 % of the circulating calcium and is a co-transporter of hormones such as thyroxine , cortisol , testosterone , among others Main carrier of fatty acids Also binds to drugs and unconjugated bilirubin- making them less toxic Scavenges free oxygen radicals - antioxidant and exerting an antiplatelet effect ( prevents platelet aggregation )

Causes of low albumin include-Decreased production , Defective synthesis for e.g due to hepatocyte damage , Deficient intake of amino-acids , Increased loss of albumin - this can be via GI tract renal process skin acute or chronic inflammation

Serum albumin levels are reggulated by -rate of hepatic synthesis and secretion exchanges between the intravascular and extravascular compartments lymphatic uptake alterations in volume of distribution protein degradation bosy losses

It can cause -peripheral and central oedema...