Malignant pleural mesothelioma

Malignant pleural mesothelioma ( MPM ) is a rare and aggressive malignancy arising from the mesothelial cells lining the pleural cavity ( Patel et al 2016 )

aggressive malignancy of the pleural surface associated with previous asbestos exposure insidious neoplasm long latent period after exposure to asbestos ranging from 20-70 yrs originates from mesothelial surfaces of the tissues of pleura but can also happen in the pericardium and tunica vaginalis most commonly affected is the pleural layer causing MPM amosite and crocidolite ( most tumorigenic ) - variants of asbestos are strongly associated with MPM risk depends upon the type of fibre that the individual was exposed to and the duration peak incidence in 5th and 6th decade of life male preponderance ( occupational nature of disease )

Risk factors -exposure to asbestos ( used widely due to fire-resistant properties ) professions associated with ship building, mining , ceramics , cement , auto parts particularly brake lining , paper mill , insulation , railroad repair smoking is not linked with MPM but smoking and asbestos exposure together would increase the risk significantly demolition work electricians , plumbers and launderers it is also thought that individuals with germline BRCA1 associated protein...