Migraine

Complex neurological disorder that affects multiple cortical, subcortical and brainstem areas that regulate autonomic, affective, cognitive and sensory functions

Primary Headache- the disorder is the headache itself ( as in migraine , tension type headache and cluster headache ) Secondary Headache -headache is a symptom of a secondary abnormality such as dental pain , SAH or brain tumour

How common-Migraine has a prevalence of about 12 % globally and contributes to around 40-50 % of the overall headache burden Chronic migraine affects 1-2 % of global population Most common severe primary headache disorder Second most disabling disease worldwide Frequently starts in childhood , particularly around puberty and affects women ↑ than men ( 3 : 1 female to male ratio ) Migraine is the most prevalent neurological disorder in men Affects people during the formative and most productive periods of their lives - between age 15-49 with a peak prevalence between ages 35-39 yrs Tends to run in families and as such is considered a genetic disorder- some estimates quote heritability to be as high as 50 % and with a likely polygenic multifactorial inheritance The more disabling the migraine ↑ likely there is to be familial connection

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