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Neck lumps : differentials

These simplified tables aim to offer clinicians a quick overview of the epidemiological considerations when dealing with neck lumps. It highlights the importance of detailed assessment and thoughtful management, especially given the variety of possible etiologies.

Why important: data shows that

Epidemiological FactorsData & Notes
General IncidenceLacking specific data due to the self-limiting nature of most inflammatory neck masses.
Malignant Neck MassAbout 30,000 of the 62,000 cases of head and neck cancer diagnosed in 2016 presented with a malignant neck mass.
Benign Neck MassAn estimated additional 30,000 patients will present with a persistent neck mass of benign aetiology.
Lateral Neck Masses in Adults >40 yearsMore than 75% are caused by malignant tumours.
Neoplastic Cervical AdenopathyIncidence increases with age.
Disease GroupingsIn a study of 8500 patients: 40% had metastatic squamous cell carcinoma, 39.5% had lymphoma, 16.5% benign, 2% sarcoma, 2% chemodectomas.
Origin of Metastatic Squamous Cell Carcinoma74% developed from head and neck primaries; 11% from primaries outside that region.
Significance in ChildrenMost likely to have benign cause such as reactive cervical lymphadenopathy.
Single Neck LumpsOften due to congenital cause or inflammation.
Malignancy in ChildrenRare; includes lymphomas, thyroid cancer, and soft...

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