Ovarian cancer

Ovarian cancer

Seventh most commonly diagnosedcancer globally. In UK highestincidence in females between 75-79Usually affectswomen > 65

The most important risk factor for ovarian cancer is a family history of breast or ovarian cancerIncidence of OC is rising in the UK

Most lethal gynaecological malignancy-Poor prognosis as presents late due toasymptomatic development -often diagnosed at advanced stage ( called silent killer )

Treatment options have seen major new developments with innovation for e.g in biomarker development , PARP inhibitors , immunotherapy etc- substantially increasing survival

Risk factors-Increasing age - rare below 40 without inheritable component Infertility Family history- one of the strongest and most significant risk factor○ the more family members with ovarian cancer are the more they are likely to get the disease○ about 18 % of EOC cases are associated with a germline mutation○ amplified threat is associated with family h/o other cancers as colorectal and breast cancer Endometriosis PCOS Older age at menopause Hormone replacement therapy ( data not very clear and magnitude may be moderate ) Early age at menarche and late age at menopause Cigarette smoking ( mucinous carcinomas ) Pelvic inflammatory disease Obesity Diet ( if this is a risk or not remains unresolved...