Pagets disease of bone – quick review card

Pagets disease of the bone - Focal skeletal disorder of bone remodelling

Non-inflammatory ,metabolic disorder , Excessive localised bone resorption via osteoclasts , Increased compensatory osteoblastic activity to compensate for excessive localised bone loss , Leads to unstructured , fibroblastic , biomechanically unstable bone , deformity & enlargement , Poor quality bone with both sclerotic & lytic areas

How common - chronic focal high bone turnover disorder second most common metabolic bone disorder after osteoporosis affects about 1 % to 2 % of the population and mostly people > 55 more common in men often runs in families ( up to 40 % of cases ) with autosomal dominant pattern of inheritance seen more commonly in people of British descent it is thought that incidence of PDB has decreased in most regions over recent years

also known as osteitis deformans first described in 1876 by London physician J Paget it may affect a single bone , several or many bones but does not affect the whole skeleton cause remains unknown but environmental factors as viral infection has been implicated (likely multifactorial ) osteoclasts which are abundant in Paget's lesion have been found to be different - ie they are larger...