Pharmacological interventions for dementia : an overview

" This table provides a concise summary of the NICE recommendations on pharmacological treatments for various dementia subtypes. It outlines the recommended medications, their stages of applicability, and the mechanisms behind their use, aiming to offer clinicians a quick reference guide for dementia management.

Dementia Type/Aspect	Recommendations & Interventions
General Guidance
Alzheimer's Disease	- Mild to Moderate stages: Use AChE inhibitors: donepezil, galantamine, or rivastigmine. - For those intolerant to AChE inhibitors or with severe disease: Use Memantine. - Initiation: Should be under the advice of a specialist (like psychiatrist, geriatricians). - Continuation: Primary care can continue prescriptions after initiation. - Assessment: Relying solely on cognition scores is discouraged; consider the patient's overall condition. Medications to Avoid: Do not use specific medicines like diabetes drugs, hypertension drugs, statins, or NSAIDs specifically to slow Alzheimer's disease progress.
Dementia with Lewy Bodies	- Mild to Moderate stages: Offer donepezil or rivastigmine. - If donepezil and rivastigmine aren't tolerated: Consider galantamine. - Severe stages: Consider donepezil or rivastigmine. - When AChE inhibitors aren't tolerated: Consider memantine.
Vascular Dementia	- AChE inhibitors or memantine should be considered only if there is suspected comorbidity with Alzheimer's disease, Parkinson's disease dementia, or dementia with Lewy bodies....

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