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Norethisterone, a synthetic form of progesterone, is commonly used in primary care to delay menstruation. This medication is particularly beneficial for women seeking to postpone their menstrual cycle due to various reasons such as convenience, special occasions, or medical conditions. Norethisterone works by maintaining high levels of progesterone, thus preventing endometrial shedding that triggers menstruation. While effective, its prescription requires careful consideration of the patient's medical history, including potential contraindications and drug interactions. Regular follow-up is essential to monitor effectiveness and manage any side effects. This introduction provides an overview of Norethisterone's use, emphasizing its role, efficacy, and the necessary precautions for safe and effective treatment.
About NET
| Aspect | Details |
|---|---|
| Pharmacotherapeutic Group | ATC Code L02A B** |
| Mechanism of Action | Suppresses ovulation by affecting the pituitary; reduces endogenous estrogens and progesterones; transforms ectopic endometrium; may act directly on tumour deposits in carcinoma |
| Pharmacokinetics | Rapid and complete oral absorption; peak plasma concentration in 1-3 hours; 60% bioavailability compared to IV; elimination half-life of 5-12 hours; mainly metabolized in the liver |
| Excretion | Approximately 60% excreted as metabolites in urine and faeces |
| Contraindications (CIs) | Hypersensitivity, pregnancy, venous or arterial thromboembolism, liver dysfunction, certain pregnancy-related conditions, unexplained vaginal bleeding, porphyria |
| Special Cautions | Caution in the... |
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