Primary hyperparathyroidism – Quick review chart

Disorder of the parathyroid glands in which one or more of the parathyroid glands are enlarged ( hyperplastic ) , overactive and secrete too much parathyroid hormone.

relatively common endocrine disorder most common cause of hypercalcemia in ambulatory setting happens more commonly in women , age 50-60 studies have shown an annual incidence of 20 cases per 100,000 people with an estimated prevalence in the general population of 0.5 % to 1 % and this increase with age to over 2 % in both sexes

solitary parathyroid adenoma ( 80 % of cases ) diffuse hyperplasia and multiple adenomas familial disorders ( e,g MEN type 1 ,2A syndrome ) parathyroid carcinoma ( rare ) familial hypocalciuric hypercalcemia is a benign cause , autosomal dominant inheritance ( mimics PHPT )

Hypercalcemia and levels of PTH that are inappropriately high for the level of hypercalcemia ( normally the PTH level would be suppressed ) , in some cases the PTH can be within the reference range Even a normal PTH in presence of hypercalcemia is inappropriate and consistent with PTH-dependent hypercalcemia Previously patients were detected when they presented with complications as kidney stones , bone pain or deformity- now usually an incidental...