Reactive arthritis

Reactive arthritis ( ReA ) is one of the seronegative spondyloarthropathies ( these include ankylosing spondylitis , psoriatic arthritis , Inflammatory bowel disease and undifferentiated SpA - closely linked with HLA-B27 gene ) It is a sterile inflammation of the synovial membranes , fascia and tendons triggered by an infection at a distal site ( BASH National Guideline on the Management of Sexually Acquired Reactive Arthritis 2019 )

Due to enteric infection with gastrointestinal pathogens as Salmonella , Shigella , Campylobacter

ReA is a group of conditions -associated with HLA-B27 gene - ie these conditions manifest some shared rheumatic features as enthesitis , sacroiliitis , peripheral arthritis and associated extra-articular lesions particularly psoriasis , uveitis and inflammatory bowel disease Previously described as Reiter's disease with classic triad of arthritis , urethritis and conjunctivitis ReA is precipitated by an infection at a distant site and genetic susceptibility , marked by possession of the HLA B27 gene It is thought an aberrant immune response to the infectious pathogens leads to ReA ( proliferative T cell response targets autoantigens causing inflammation and tissue destruction ) Chlamydophila pneumoniae - is also an accepted cause of ReA , however it is less frequent than that...