Sulfasalazine

Sulfasalazine is a synthetic salicylic acid derivative with an affinity for connective tissue containing elastin and formulated as a prodrug , antiinflammatory Sulfasalaine acts locally in the intestine through its active metabolite , sulfamide 5-aminosalicylic acid and salicylic acid , by a mechanism that is not clear ( Pubchem )

Salazopyrin En-Tabs 500 mg tablets also comes with Enteric coating to reduce GI SEs Typical regimen may start with 500 mg / day ↑ ed at intervals of 1 week by one 500 mg tablet a day to a max of 2-3 gm in divided doses

Ulcerative Colitis -induction and maintenance of remission Crohn's disease - treatment Rheumatoid arthritis Sero negative spondylo-arthopathy ( including psoriatic arthritis and Psoriasis ) Can be used as monotherapy or in combination

Is a prodrug Structurally related to both salicylates ( for eg aspirin ) and sulphonamides Split by bacterial in colon into Sulfapyridine ( SP ) & Mesalazine MP ) Precise mechanism of action not know Local actions of mesalamine in colon - likely reason for effectiveness in inflammatory bowel dis RA- may be related to anti-inflammatory and immunomodulatory properties In rheumatoid arthritis a disease-modifying effect is seen in 1-3 months ( reduction in...