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Tinnitus : medication induced

The management of tinnitus often involves a multidimensional approach, including identifying and modifying potential causative factors. One such critical factor is medication-induced tinnitus. The following table provides an overview of various medication categories and specific medications that have been associated with the induction of tinnitus.


Understanding the ototoxic potential of these medications is essential for clinicians, as it not only aids in the diagnostic process but also guides treatment and preventive measures. The table outlines the rationale for tinnitus induction based on existing pathophysiological mechanisms, where applicable. This information is particularly useful for clinicians when prescribing medications to patients who already have tinnitus or are at risk of developing it.


The categories range from commonly used antibiotics and analgesics to more specialized medications such as antiviral agents and cytotoxic drugs. It's crucial to note that while some drugs have well-established ototoxic profiles, others may cause tinnitus through less clear or idiosyncratic mechanisms.

Medication CategorySpecific MedicationsRationale for Tinnitus Induction
AntibioticsClarithromycin, Ciprofloxacin, TetracyclineOtotoxicity; direct damage to inner ear structures
AntiviralsGanciclovirOtotoxicity; potential cochlear or neural damage
AnalgesicsAspirin, Ibuprofen, Piroxicam, CelecoxibOtotoxicity; may affect cochlear function leading to tinnitus
Cardiac DrugsFurosemide, Amiloride, Metoprolol, Ramipril, Enalapril, Diltiazem...

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