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Managing fungal skin infections effectively is a common concern for primary care practitioners in the UK. Whether it's tinea infections like athlete's foot and jock itch or more complex issues like candidiasis, the choice of treatment often comes down to topical antifungals. This guide aims to provide an in-depth look at the two major classes of topical antifungal agents available in the UK: Allylamines and Azoles. We will discuss commonly used drugs in these categories, their key indications, available formulations, and typical duration of treatment. Please always refer to the BNF before prescribing and for specific instructions.
Class | Drug Name | Common Indications | Formulations | Typical Duration | Comments & Considerations | References |
---|---|---|---|---|---|---|
Allylamines | Terbinafine | Tinea pedis, Tinea cruris, Tinea corporis | Cream, Gel, Spray | 1-4 weeks | First-line for many dermatophyte infections. Rapid fungicidal action. | NICE CKS, Fungal Skin Infection |
Allylamines | Naftifine | Tinea pedis, Tinea cruris | Gel | 2-4 weeks | Less commonly used. Potential for local irritation. | NICE CKS, Fungal Skin Infection |
Azoles | Clotrimazole | Candidiasis, Tinea infections | Cream, Solution | 2-4 weeks | Broad spectrum but fungistatic. | BNF 2021 |
Azoles | Miconazole | Candidiasis, Tinea infections | Cream, Powder | 2-4 weeks | Also has some antibacterial properties. | BNF 2021 |
Azoles | Ketoconazole | Tinea infections, Seborrhoeic dermatitis | Cream, Gel | 2-4 weeks | Limited by potential... |
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