Antidepressant Discontinuation Syndrome

Antidepressant Discontinuation Syndrome refers to a constellation of symptoms that may occur following the abrupt cessation or significant reduction in the dose of an antidepressant medication that has been taken continuously for a period of time, typically at least one month. This syndrome is a well-recognized phenomenon and can occur with any class of antidepressant, although the risk and symptom profile may vary depending on the specific medication and its half-life.

The syndrome is characterized by a range of symptoms that can include flu-like effects, insomnia, nausea, imbalance, sensory disturbances, and hyperarousal. These symptoms are often described as being quite distressing and can significantly impact a patient’s quality of life. They typically arise within a few days of discontinuing the medication and generally resolve within one to two weeks, although in some cases, they may persist for longer periods.